Scientists have long known that VEGF is vital for normal advancement of the vascular system and for wound curing. It triggers the forming of new blood vessels that nourish the growing body and heal cells and organs. VEGF also stimulates – – within an apparent misguided attempt to heal perceived harm in the retina – – the growth of abnormal blood vessels that leak and harm delicate retinal tissue. However, an evergrowing body of evidence indicates that beyond its impact on blood vessel growth also, VEGF may play various other vital functions in the adult body and eye, in order that eliminating the development factor might lead to unexpected consequences.Two of three research susceptible to bias Three randomized managed trials were available to IQWiG. Two studies compared antibody-stents with DES; one study compared antibody-stents with BMS. One DES study and one BMS research had only a few individuals and were prematurely discontinued. These discontinuations were not planned, i.e. The criteria for stopping the scholarly studies was not specified before the start of studies. Moreover, it had been unclear in one of the studies whether the randomized allocation to the two treatment groups was adequately concealed.